​​​​​​​​​​​​​​Ongoing and Completed Projects, All Funding Mechanisms


[2022 Continued Funding] Objective cardiac testing following emergency department evaluations for chest pain: associations between referral for non-invasive cardiac testing and 2-year adverse outcomes.
Dustin Mark | CH | Ongoing

Acute Emergency Care and Outcomes for Stroke, Myocardial Infarction, and Surgery During the COVID-19 Pandemic in Kaiser Permanente Northern California: Implications for Care Delivery During COVID-19 Recovery Phase and Future Surges
Mai Nguyen-Huynh, Matthew Solomon, David Vinson, Robert Chang | Other | Ongoing

Addressing Age and Blood Pressure  – Utilizing a National Database
Ashok Krishnaswami | Other | Ongoing

Changes in weight, lipids, blood pressure, health care utilization and CV outcomes in participants of the Medical Weight Management Program
Ashok Krishnaswami | Other | Ongoing

Characterizing the development of cardiovascular disease in women after adverse pregnancy outcomes.
Victoria Woo | CH | Ongoing

Coronary Artery Risk Development in Young Adults (CARDIA) Study
Jamal Rana | NIH | Ongoing

CORVIA 1601 REDUCE LAP HF: A study to evaluate the Corvia Medical, Inc. IASD® System II to REDUCE Elevated Left Atrial Pressure in Patients with Heart Failure
Ann Sheridan | Industry | Ongoing

Deprescribing CV and non-CV medications
Ashok Krishnaswami | Other | Ongoing

EDWARDS 2017-05 ACTIVE: A trial to assess transcatheter mitral valve repair with Edwards Cardioband System and guideline directed medical therapy (GDMT) compared to GDMT alone in patients with functional mitral regurgitation (FMR) and heart failure
Andrew Rassi | Industry | Ongoing

EDWARDS 2018-07 CLASP III: A trial to evaluate safety and effectiveness of transcatheter mitral valve repair with the Edwards PASCAL Transcatheter Mitral Valve Repair System compared to Abbott MitraClip in patients with degenerative mitral regurgitation
Andrew Rassi | Industry | Ongoing

EDWARDS EARLY TAVR: Evaluation of Transcatheter Aortic Valve Replacement Compared to Surveillance for Patients with AsYmptomatic Severe Aortic Stenosis: EARLY TAVR trial 2016-07 EARLY TAVR SAPIEN 3 Transcatheter Heart Valve G160259
Richard Richter | Industry | Ongoing

Evidence Based Evaluation and Acceptance of Donor Hearts for Transplantation
Jon Zaroff, Kiran Khush | NIH | Ongoing

Examination of the Acute Effects of Azithromycin Use on Cardiovascular Mortality, as Compared with Amoxicillin and Levofloxacin
Jon Zaroff | Pfizer | Ongoing

GUARD AF: Screening for atrial fibrillation in high risk patients
Alan Go, Drew Ambrosy, Matt Solomon | Industry | Ongoing

Hypercoagulability in mechanical circulatory support
Sirtaz Adatya | Industry | Ongoing

Improved Outcomes with Home-Based Cardiac Rehabilitation-Experience from a Large Integrated Heathcare System
Uma Vadlakonda, Mary Reed, Bradley Frueh | RAU | Ongoing

Improving Care by Defining the Role of ElectroNic HealTh Record-Based Alerts In a Fully Integrated Health Care Delivery SYstem for Worsening Heart Failure (IDENTIFY-WHF)
Drew Ambrosy | DSGP | Ongoing

Improving quality by TARGETing LDL using a systems-based approach to evaluate our current performance (TARGET-LDL)
Adam Rogers, Carlos Iribarren | DSGP | Ongoing

KP Post-PCI Outcomes and Resource Utilization Study, and Development and Validation of a KP Post-PCI Risk Calculator
Matt Solomon | Industry | Ongoing

KP Real-world Heart Monitoring StrategY Evaluation, Treatment Patterns and Health Metrics (RHYTHM) Study
Matt Solomon, Alan Go | Industry | Ongoing

MEDTRONIC APOLLO: Transcatheter Mitral Valve Replacement with the Medtronic Intrepid™ TMVR System in patients with severe symptomatic mitral regurgitation
Jacob Mishell | Industry | Ongoing

MITRALIGN CLPR- 010 SCOUT: Early Feasibility Of The Mitralign Percutaneous Tricuspid Valve Annuloplasty System (Ptvas) For Symptomatic Chronic Functional Tricuspid Regurgitation CLPR-010
Andrew Rassi | Industry | Ongoing

Multicenter Arteriovenous malformation Research Study (MARS) extension
Jon Zaroff, Helen Kim | NIH | Ongoing

Optimizing Management of Valvular Heart Disease
Matthew Solomon, MD, PhD | PRP | Ongoing

PIONEER-HF: A large, multi-center randomized clinical trial of sacubitril- valsartan versus enalapril in heart failure
Drew Ambrosy | Industry | Ongoing

Pregnancy outcomes in women with cardiovascular disease: a retrospective cohort study from Kaiser Permanente Northern California
Seema Pursnani | CH | Ongoing

Pulse Pressure, Treatment Intensity in Participants of the SPRINT trial
Ashok Krishnaswami | Other | Ongoing

Systematic Review of the role of age in cardiac imaging
Ashok Krishnaswami | Other | Ongoing

Sahar Naderi | Other | Ongoing

Use of Elixhauser Comorbidity Index in risk stratifying participants referred for Permanent Pacemaker placement
Ashok Krishnaswami | Other | Ongoing

Validation of a Novel Algorithm for Emergency Department Patients with Possible Acute Coronary Syndromes Following the Transition to a High-Sensitivity Troponin Assay
Dustin Mark, Mary Reed | DSGP | Ongoing

Familial hypercholesterolemia II - manuscript
Richard Birnbaum, Andy Avins | RAU | Not Started

Accuracy of Prenatal Detection of Clinically Significant Congenital Heart Disease Among Still- and Live-Births at Kaiser Permanente Northern California
Kavin Desai, Lisa Herrinton | RAU | Completed | View Summary

Adherence to Guideline Recommendations for Secondary Prevention and Mortality after Acute MI
Matt Solomon, Alan Go | Industry | Completed

Assessing Glycosylated Hemoglobin (HbA1c) Thresholds for Development of Cardiovascular Disease by Racial-Ethnic Groups
Seema Pursani | CH | Completed

BSC S2073 EVOLVE: Study assessing safety of 3-month dual antiplatelet therapy (DAPT) in subjects at high risk for bleeding undergoing percutaneous coronary intervention (PCI) with the SYNERGYTM Everolimus-Eluting Platinum Chromium Coronary Stent System
Andrew Rassi | Industry | Completed

CABG vs PCI in Older Acute Coronary Syndrome (ACS) patients: Impact of revascularization strategy on outcomes
Ahmed Shah | CH | Completed

Clinical Characteristics, Periprocedural Complications, and Outcomes of Patients with Severe Aortic Stenosis Undergoing Elective versus Urgent/Emergent Transcatheter Aortic Valve Replacement within an Integrated Health Care Delivery System
Mishell, Jacob MD | CH | Completed

Clopidogrel Duration after Chronic Total Occlusion Percutaneous Coronary Intervention
Amit Sachdeva | CH | Completed

Comparison of high risk elective percutaneous coronary intervention in CV surgery back-up sites versus non-CV surgical back-up sites
Shah, Ahmed MD | CH | Completed

Contemporary Risk Stratification in Adults with Heart Failure and Reduced Ejection Fraction
Adatya, Sirtaz, MD | CH | Completed

Development of chronic thromboembolic pulmonary hypertension after acute pulmonary embolism
Choon Goh | CH | Completed

Duration of thienopyridine therapy and outcomes after PCI for chronic total occlusions
Amit Sachdeva | CH | Completed

EDWARDS 2015-08 AVIV: A Prospective, Single-Arm, Multicenter Study to Investigate the Safety and Effectiveness of SAPIEN 3 Transcatheter Heart Valve Implantation in Patients With a Failing Aortic Bioprosthetic Valve
Edward McNulty | Industry | Completed

EDWARDS 2015-08 P3: A study to establish the safety and Effectiveness of the Sapien 3 Transcatheter Heart Valve in low risk patients who have severe, calcific, aortic stenosis requiring Aortic Valve Replacement
Edward McNulty | Industry | Completed

Effect of lipid (LDL) monitoring on patients’ statin adherence and physician practice behaviors after an ASCVD event.
Rana, Jamal MD PhD | CH | Completed

Epidemiology and Outcomes for Thoracic Aortic Aneurysms and Acute Aortic Dissections
Matt Solomon | CH | Completed

EVALVE 11-512- COAPT: A Clinical Evaluation of the Safety and Effectiveness of the MitraClip® System for the Treatment of Functional Mitral Regurgitation in Symptomatic Heart Failure Subjects
Jacob Mishell | Industry | Completed

Heart failure readmission intervention
Keane Lee, Alan Go | DSGP | Completed

Identification and management of familial hypercholesterolemia in an integrated health care delivery system.
Richard Birnbaum | RAU | Completed | View Summary

Impact of wildfire air pollution on rates of cardiovascular events and mortality
Stacey Alexeeff | CH | Completed

Implementation of Familial Hypercholesterolemia and template transition protocol
Richard Birnbaum, Andy Avins | RAU | Completed

Interaction Between Choice of Anticoagulation, Antiplatelet Therapy and Access Site on Mortality and Bleeding after Percutaneous Coronary Intervention: Insights from the California National Cardiovascular Data Registry ( NCDR) and KP PCI Registry
Femi Philip | CH | Completed

Management and outcomes of patients with valvular heart disease
Matt Solomon, Alan Go | PRP | Completed | View Summary

Management OptiminzatioN vIa TelemOnitoring and Resource utilization and outcomes in Heart Failure (MONITOR-HF)
Amir Axelrod, Andrew Ambrosy, Alan Go | DSGP | Completed

Rate versus Rhythm Control in Young Patients with Atrial Fibrillation: The KP YOUNG-AF Study
Matthew Solomon | CH | Completed

Severe Hypoglycemia and Risk of Atherosclerotic Cardiovascular Disease (ASCVD) in Patients with Diabetes
Jamal Rana | CH | Completed

Status and impact of Ideal Cardiovascular Health, as defined by American Heart Association, among KPNC population
Jamal Rana | CH | Completed

The Use of Natural Language Processing to Characterize Episodes of Outpatient Worsening Heart Failure within an Integrated Health Care Delivery System
Ambrosy, Andrew, MD | CH | Completed

Ticagrelor vs. Clopidogrel in Acute Coronary Syndromes: A Real-World, Community-Based Comparison of Ischemic and Bleeding Outcomes
Amit Sachdeva | CH | Completed

Transcatheter aortic valve replacement – Personalizing risk for quality of life, developing complications, total mortality, and utilization (TAVR - PREDICT) Study
Ed McNulty, Alan Go | DSGP | Completed

Use and outcomes of CT angiography
Jamal Rana, Alan Go | DSGP | Completed | View Summary

A Pragmatic Randomized Controlled Trial of a Bundled, Pharmicist-Led Hyper-polypharmacy Deprescribing Intervention
Lynn Deguzman, Maisha Draves, Lisa Herrinton | Other |

Assessing the impact of the COVID-19 pandemic on glycemic control and covid-19 infection in diabetic patients
Seema Pursnani | Other |

Association of multimorbidity in older adults after permanent pacemaker placement
Ashok Krishnaswami | Not funded (support from Implant registry) |

Atherosclerotic cardiovascular disease risk in South Asians by statin use
Seema Pursnani | Other |

Clinical Characteristics of COVID-19 in Solid Organ Transplant Recipients
Dana Weisshaar | Other |

Comprehensive assessment of harm and benefit in SPRINT
Ashok Krishnaswami | Other |

Disparities in Redidual Risk in Patients Reveiving Statins for Primary or Secondary Prevention at an Integrated Health Care Delviery System (KP Reach)
Andrew Ambrosy | Industry |

Duration of Dual Antiplatelet Therapy After Percutaneous Coronary Intervention for Chronic Total Occlusion
Amit Sachdeva | CH |

Effectiveness of Care Processes Recommended to Improve Perioperative Cardiovascular Risk Management for Noncardiac Surgery
Lisa Herrinton | Other |

Evaluating Inpatient and Outpatient Encounters Within a Learning and Integrated Health Care Delivery Organization Due to Worsening Heart Failure
Andrew Ambrosy, Alan Go | Industry |

Healthy Eating as a Means for Active Living in Heart Failure (HEAL-HF)) Study
Andrew Ambrosy, Alan Gl, Nancy Gordan | CH |

HIV Infection and Risks of Morbidity and Death in Adults with Incident Heart Failure
Alan Go, Michael Siverberg | Other |

HIV Risk of Developing Heart Failure by Age, Gender and Race/Ethnicity: The HIV HEART Study
Alan Go, Michael Siverberg | Other |

Long-term follow up of maternal outcomes in peripartum cardiomyopathy
Seema Pursnani | Other |

Long-Term Outcome in Unruptured Brain Arteriovenous Malformation Patients
Helen Kim | NIH |

Natural History of Thoracic Aortic Aneurysm and Acute Aortic Dissection
Matt Solomon | CB |

Outcomes of the Heart Health for South Asians (HHSA) Program
Seema Pursnani | Other |

Periprocedural Code Status for TAVR
Gwen Bernacki | Other |

Predictors of Post-PCI Resource Utilization and Outcomes
Matt Solomon | Industry |

Transcatheter Mitral-Valve Repair in Patients with Heart Failure and Functional Mitral Regurgitation - Potential Scope and Clinical Benefit of Early Adoption at an Integrated Healthcare Delivery System
Andrew Ambrosy | Industry |

Understanding the impact of race/ethnicity and gender on cardiovascular outcomes following CABG
Seema Pursnani | Other |