​​​​​​​​​​​​​​Ongoing and Completed Projects, All Funding Mechanisms


A Phase 1, Open-Label Dose-Finding Study To Evaluate Safety, Tolerability, And Immunogenicity And Phase 2/3 Placebo-Controlled, Observer-Blinded Safety, Tolerability, And Immunogenicity Study Of A Sars-Cov-2 Rna Vaccine Candidate Against Covid-19 In H
Nicola Klein | Pfizer | Ongoing

A Virtual Network to Investigate the Effectiveness of COVID-19 and influenza vaccines and evaluate the burden and epidemiology of respiratory viruses
Nicola Klein, Ousseny Zerbo | CDC | Ongoing

Acute Emergency Care and Outcomes for Stroke, Myocardial Infarction, and Surgery During the COVID-19 Pandemic in Kaiser Permanente Northern California: Implications for Care Delivery During COVID-19 Recovery Phase and Future Surges
Mai Nguyen-Huynh, Matthew Solomon, David Vinson, Robert Chang | Other | Ongoing

Assess influenza and COVID-19 vaccination coverage among pregnant women using automated data in VSD
Nicole Klein | Other | Ongoing

Assessing the impact of changes in health care utilization during the COVID-19 pandemic on background rate trends and use of telemedicine encounters for vaccine adverse events of special interest
Nicole Klein | Other | Ongoing

Clinical Immunization Safety Assessment (CISA): COVID Consult                                                                  
Nicola Klein | Other | Ongoing

Comparison of Cross-Sex Hormone Therapies in Relation to Risks of Vascular Events: Characteristics of the COVID-19 Epidemic in Transgender Populations
Michael Silverberg | PCORI | Ongoing

COVID surveillance (CDC Vaccine Safety Datalink population-based surveillance)
Nicola Klein | Other | Ongoing

COVID-19 Infrastructure and Activities Vaccine Safety Datalink Project, VSD COVID-19 Infrastructure and Participating Activities
Li, De-Kun. | Other | Ongoing

COVID-19 Pandemic: Impact on Colorectal Cancer Screening and Adenoma Surveillance Outcomes (PICASO)
Theodore Levin | Other | Ongoing

COVID-19 Population Based evaluation of COVID-19 cases
Nicole Klein | Other | Ongoing

COVID-19 Pregnancy and Fetal Death
Nicole Klein | Other | Ongoing

COVID-19-Associated Hospitalization Surveillance in Children and Adults
Jacek Skarbinski | Other | Ongoing

COVID-19-Related Enhancements to "Evaluation of complex interventions on drug (re)fill behavior using electronic healthcare data"
Neugebauer, R, | PCORI | Ongoing

Cross-Cohort Collaboration on COVID-19 Research (4CR)
Steve Sydney | Other | Ongoing

Effectiveness and safety of treatments for hospitalized patients with COVID-19
Liu, V. | Other | Ongoing

Examining the "Hidden Epidemic": Consequences of COVID Social Distancing and Health Care System Responses among Patients with Complex Medical and Social Needs
Grant, R. | Other | Ongoing

Expanded Access to Convalescent Plasma for the Treatment of Patients with COVID-19
Waldron, P. | Other | Ongoing

Identifying Pre-Sepsis Opportunities for Early, Targeted Intervention - COVID19
Liu, V. | NIH | Ongoing

Innovative Methods to Inform Estimates of Vaccine Effectiveness Using Information on the Epidemiology and Incidence of Influenza and Other Acute Respiratory Illnesses
Nicola Klein | Other | Ongoing

Innovative Methods to Inform Estimates of Vaccine Effectiveness Using Information on the Epidemiology and Incidence of Influenza and Other Acute Respiratory Illnesses
Nicola Klein, Ousseny Zerbo | Other | Ongoing

K23: Impact of gestational SARS-CoV-2 and maternal inflammation on child growth and neurodevelopment in a malaria-endemic setting
Karen Jacobson, Nicola Klein | NIH | Ongoing

NA-ACCORD Corona Infectious Virus Epidemiology Team (CIVETs)
Michael Silverberg | NIH | Ongoing

Optimizing quality and safety in the era of COVID-19: Virtual care first utilization and outcomes for potentially emergent conditions among KPNC members
Kene, M. | Other | Ongoing

Perinatal COVID-19 Infection National Registry
Fischer, A. | Other | Ongoing

Post-Acute Sequelae of SARS-Cov-2 Infection (PASC) in Adult KPNC Members
Mary Reed, Dustin Ballard | DSGP | Ongoing

R01: COVID- 19 Vaccine Effectiveness in Pregnant Women and Their Infants                                                  
Ousseny Zerbo | NIH | Ongoing

Rapid Cycle Analysis of COVID-19 vaccine(s)
Nicole Klein | Other | Ongoing

SARS-CoV-2 Serological Antibody Testing for Disease Surveillance and Clinical Use
Jacek Skarbinski, Larry Kushi, Douglas Corley | NIH | Ongoing

SARS-COV-2 vaccine safety evaluation in pregnant women and their infants
Nicole Klein | Other | Ongoing

The impact of COVID-19 pandemic on health status and healthcare utilization among adults with autism spectrum disorders
Lisa Croen | Other | Ongoing

VSD: COVID Vaccine Safety Rapid Cycle Analysis
Nicola Klein | Other | Ongoing

VSD: Vaccination coverage in school-age children pre and post pandemic for COVID-19 and other recommended childhood vaccines
Kristin Goddard, Nicola Klein | Other | Ongoing

A Phase II, single-blind, randomized, controlled study to evaluate the immunogenicity and safety of a measles, mumps, rubella, varicella vaccine compared with ProQuad, administered in healthy children 4 to 6 years of age (GSK 217715 [MMRVNS 20-001])
Nicola Klein | Other | Not Started

COVID-19 Lattice Swab Evaluation Study
Doug Corley | RAU | Not Started

A learning health care system in action: Kaiser Permanente Northern California’s response to the COVID-19 pandemic
Gabriel Escobar, Laura Myers, Vincent Liu | DSGP | Completed | View Summary

A Multi-center, Multi-country Retrospective Cohort Study to Evaluate the Clinical Outcomes in Adults with Severe COVID-19
Alan Go | Other | Completed

A multicenter, randomized, placebo-controlled, pragmatic Phase 3 study investigating the efficacy and safety of rivaroxaban to reduce the risk of major venous and arterial thrombotic events, hospitalization and death in medically ill outpatients with acut
Alan Go | Industry | Completed

A Phase 1, Open-Label Dose-Finding Study To Evaluate Safety, Tolerability, and Immunogenicity and Phase 2/3 Placebo Controlled, Observer-Blinded Safety, Tolerability, and Immunogenicity Study of SARS-CoV-2 RNA Vaccine Candidate Against COVID-19 In Healt
Nicole Klein | Other | Completed

A Phase 2 Randomized Single-Blind Study to Evaluate the Activity and Safety of Low Dose Oral Selinexor (KPT-330) in Patients with Severe COVID-19 Infection (XPORT-CoV-1001)
Jacek Skarbinski | Industry | Completed

A Phase 3 Master Protocol to Evaluate Additional Dose(s) of BNT162B2 in Health Individuals Previously Vaccinated with BNT162B2
Nicole Klein, Elizabeth McGlynn | Other | Completed

A Phase 3 Randomized Study to Evaluate the Safety and Antiviral Activity of Remdesivir (GS-5734™) in Participants with Severe COVID-19
Jacek Skarbinski (PI), Somalee Banerjee et al | Industry | Completed

A Phase 3 Randomized Study to Evaluate the Safety and Antiviral Activity of Remdesivir (GS-5774) in Participants with Moderate COVID-19 Compared to Standard of Care Treatment
Jacek Skarbinski | Industry | Completed

A Phase 3 Randomized, Double-Blind Placebo-Controlled Trial to Evaluate the Efficacy and Safety of Remdesivir (GS-9012) Treatment of COVID-19 in an Outpatient Setting
Jacek Skarbinski | Industry | Completed

A Phase 3, Randomized, Observer-Blind Study to Evlauate the Safety, Tolerability, and Immunogenicity of Multiple Production Lots and Dose Levels of the Vaccine Candidate BNT162b2 Against COVID-19 in Healthy Participants 12 Through 50 Years of Age
Nicole Klein | Other | Completed

A Prenatal Care Strategy that Included Telehealth had Similar Outcomes as In-Person Visits
Assiamira Ferrra, Mara Greenberg | DSGP | Completed | View Summary

Advancing Understanding of the Impact of Smoking Status on COVID
Young-Wolff, K. | Other | Completed

Association Between Injected Corticosteroids and Risk for Influenza and COVID-19
Joshua Rittenberg, Julie Schmittdiel | RAU | Completed

Association of Primary Care Telemedicine Follow-Up on Post Hospital Discharge Readmission Risk Prior to and During the COVID-19 Pandemic
Michael Yoo | CH | Completed

California Emerging Infections Program: COVID-19-associated hospitalization surveillance in children and adults
Jacek Skarbinski | Other | Completed

Characteristics and Clinical Trajectory of COVID-19 Patients Admitted from the Emergency Department
Reed, M. | RAU | Completed

Characteristics of ED Patients Who Test Positive for SARS-CoV-2 in a Community Health Setting
Dale Cotton, Mary Reed | RAU | Completed | View Summary

CISA COVID-19 Pediatric Study Kaiser
Nicole Klein | Other | Completed

Convalescent COVID-19 Plasma Expanded Access Program
Alan Go | Other | Completed

COVID-19 and Venous Thromboembolism Risk
Alan Go | PCORI | Completed

COVID-19 Complications Are Not More Common Among Immunosuppressed Populations in KPNC
Fernando Velayos, Julie Schmittdiel | RAU | Completed | View Summary

COVID-19 related changes in health care delivery and health outcomes among pregnant women and their newborns
Mara Greenberg, Assiamira Ferrara | DSGP | Completed | View Summary

Decision support and risk prediction for clinicians coping with the COVID-19 pandemic
Gabriel Escobar | Other | Completed

Descriptive Analysis of COPD patients with COVID-19
Myers, L. | Industry | Completed

Epidemiologic Analysis of Chilblains Eruptions at the time of COVID19
Patrick McCleskey. Lisa Herrinton | RAU | Completed | View Summary

Epidemiology of SARS-CoV2 Infection in Patients with Rheumatic Diseases
Lucy H Liu | CH | Completed

Evaluating the impact of cancer on COVID-19 diagnoses and outcomes
Andrea Harzstark, Julie Schmittdiel, Archana Anantharaman | RAU | Completed | View Summary

How COVID Changed Our Practice: Telehealth in TPMG Surgical Cancer Care
Gillian Kuehner , Mary Reed | RAU | Completed | View Summary

Immunity and patterns of disease exposure for COVID-19 across Kaiser Permanente Northern California
Jacek Skarbinski | PRP | Completed

Incidence of outpatient thromboembolism in patients with SARS-CoV-2 infections
Nareg Roubinian, Julie Schmittdiel | RAU | Completed | View Summary

KP NOURISH: Evaluation of the Clinical Utility of Medically-Tailored Meals in Adults with Chronic Conditions
Alan Go | Other | Completed

Maternal Marijuana Use During Pregnancy, Marijuana Legalization, and Adverse Obstetrical and Neonatal Outcomes: A 12-year Cohort Study
Young-Wolff, K. | NIH | Completed

Mental Health Service Demand in the face of COVID-19
Kathryn Ridout, Esti Iturralde | RAU | Completed | View Summary

Monitoring Shared Variation in Genomes of SARS-CoV-2 Among Persons With COVID-19 With and Without Vaccination in Northern California
Jacek Skarbinski | Other | Completed

Outreach to Enhance COVID-19 Vaccination Among Hesitant Elderly
Tracy Lieu | DSGP | Completed

Phase 1/2/3, Placebo-controlled, Randomized, Observer-blind, Dose-finding Study to Evaluate the Safety, Tolerability, Immunogenicity, and Efficacy of SARS-CoV-2 RNA Vaccine Candidates Against COVID-19 in Healthy Individuals
Nicole Klein | Other | Completed

Protective effect of prior flu vaccinations against Covid-19 infection
Stephanie Lowe | CH | Completed

Rate of Endophthalmitis After Intravitreal Injection and Cataract Surgery Prior to, During, and After the COVID-19 Pandemic
Ali Reza Gohari | CH | Completed

Retrospective analysis of incidence and health outcomes of asthma patients with COVID-19 within a large multi-site healthcare system
Lindsay Finkas, Carlos Iribarren | TAP | Completed | View Summary

Skin cancer diagnostic accuracy by physician assistants and dermatologists in a large multi-center health system before and during the COVID-19 pandemic
Peter A. Young, PA | CH | Completed

Smoking and COVID-19 Onset and Severity in a US Integrated Health Care Delivery System
Young-Wolff, K. | Other | Completed

The Impact of California Shelter-In-Place on Incidence of Gynecologic Emergencies in a Community-Based Population
Eve Zaritsky, Andy Avins | RAU | Completed | View Summary

The impact of the continous positive airway pressure treatment on the patients with obstructive sleep apnea in the peri-operative period and after COVID-19 infection
Khodadad Namiranian | CH | Completed

The impact of the use of anticoagulants and antiplatelets on the risk of hospitalization and mortality in patients with COVID-19
Ashok Pai, Gwendolyn Ho, Julie Schmittdiel | RAU | Completed | View Summary

Trend in treatment location of patients with Covid-19 infection in an integrated health system
Laura Myers, Kevin Ng | TAP | Completed | View Summary

Utilizing real world data to describe clinical and safety outcomes among hospitalized COVID-19 patients, and to create a comparator arm for a randomized controlled trial evaluating the efficacy and safety of actemra for COVID-19 patients
Jacek Skarbinski, Sara Tartof | Industry | Completed

Vaccine Enhanced COVID-19 Disease monitoring
Nicola Klein | Other | Completed

COVID and Influenza Near Real-Time Surveillance
Ousseny Zerbo | Other |

Pharmacist-Led Deprescribing Program in Hospice Patients
Vy Le | Other |