COVID-19 Flatten The Curve

The Permanente Medical Group COVID-19 Clinical Research Coordinating Team (CCRCT) supports evidence-based research in SARS-CoV-2 virus epidemiology including the diagnosis, treatment and prevention of COVID-19 and other clinical outcomes at Kaiser Permanente Northern California.

CCRCT Team Members

​Active Clinical Trials:

  • A Phase 3 Randomized Study to Evaluate the Safety and Antiviral Activity of Remdesivir (GS-5734TM) in Participants with Severe COVID-19 (San Francisco, Oakland, San Leandro, South San Francisco, Santa Clara, and San Jose Medical Centers)

  • A Phase 3 Randomized Study to Evaluate the Safety and Antiviral Activity of Remdesivir (GS-5734TM) in Participants with Moderate COVID-19 Compared to Standard of Care Treatment (San Francisco, Oakland, San Leandro, South San Francisco, Santa Clara, and San Jose Medical Centers)

  • A Phase 2 Randomized Single-Blind Study to Evaluate the Activity and Safety of Low Dose Oral Selinexor (KPT-330) in Patients with Severe COVID-19 Infection (XPORT-CoV-1001) (Oakland, San Francisco, and Sacramento Medical Centers)

  • A Phase 1/2, Placebo-Controlled, Randomized, Observer-Blind, Dose-Finding Study to Describe the Safety, Tolerability, Immunogenicity, and Potential Efficacy of SARS-Co V-2 RNA Vaccine Candidates Against COVID-19 in Healthy Adults
  • COVID-19 Lattice Swab Evaluation Study (TPMG/DARE-Rapid Analytics Unit)

  • KP NOURISH: Evaluation of the Clinical Utility of Medically-Tailored Meals in Adults with Chronic Conditions 

Active Clinical Studies:

  • Characteristics and Clinical Trajectory of COVID-19 Patients Admitted from the Emergency Department (The CREST Network/ DARE-Rapid Analytics Unit)

  • Risk of COVID-19 pandemic on immunosuppressed populations
    (DARE-Rapid Analytics Unit)

  • Decision support and risk prediction for clinicians coping with the COVID-19 pandemic

  • Evaluating the impact of cancer on COVID-19 diagnoses and outcomes
    (DARE-Rapid Analytics Unit)

  • KPNC mental health services utilization, outcomes, and associated patient characteristics during the COVID-19 pandemic (TPMG/DARE)

  • How COVID Changed Our Practice: Telehealth in TPMG Surgical Cancer Care
    (TPMG/DARE-Rapid Analytics Unit)

  • COVID surveillance (CDC Vaccine Safety Datalink population-based surveillance) (Division of Research)

  • The impact of the use of anticoagulants and antiplatelets on the risk of hospitalization and mortality in patients with COVID-19.
    (TPMG/DARE-Rapid Analytics Unit)

  • KP Research Bank member survey on  effects of  COVID-19 epidemic (Kaiser Permanente/Division of Research)

  • A Multi-center, Multi-country Retrospective Cohort Study to Evaluate the Clinical Outcomes in Adults with Severe COVID-19 (Division of Research)

  • COVID-19-Associated Hospitalization Surveillance in Children and Adults (Division of Research)

  • Smoking as a risk factor for COVID-19 onset and severity (Division of Research)

  • The impact of COVID-19 pandemic on health status and healthcare utilization among adults with autism spectrum disorders (Division of Research)

  • Innovative Methods to Inform Estimates of Vaccine Effectiveness Using Information on the Epidemiology and Incidence of Influenza and Other Acute Respiratory Illnesses (Division of Research)

  • Perinatal COVID-19 Infection National Registry (Med Center Based)

  • Effectiveness and safety of treatments for hospitalized patients with COVID-19 (DOR/Garfield Fund)

  • Acute Emergency Care and Outcomes for Stroke, Myocardial Infarction, and Surgery During the COVID-19 Pandemic: Implications for Care Delivery During COVID-19 Recovery Phase and Future Surges (TPMG/DARE, DOR, Garfield Fund)

  • Epidemiologic Analysis of Chilblains Eruptions at the time of COVID19 (DARE-Rapid Analytics Unit)

  • Incidence of outpatient thromboembolism in patients with SARS-CoV-2 infections (DARE-Rapid Analytics Unit)

  • The Impact of California Shelter-In-Place on Incidence of Gynecologic Emergencies in a Community-Based Population (DARE-Rapid Analytics Unit)

  • Impact of the COVID pandemic among individuals and families with complex medical and social needs (Garfield Memorial Fund)

  • COVID-19 pandemic: Impact on colorectal cancer screening and surveillance (Garfield Memorial Fund)

  • Identifying pre-sepsis opportunities for early, targeted intervention (National Institute of General Medical Sciences/NIH/DHHS)

  • Comparison of Cross-Sex Hormone Therapies in Relation to Risks of Vascular Events: Characteristics of the COVID-19 Epidemic in Transgender Populations (PCORI)

  • Utilizing real world data to describe clinical and safety outcomes among hospitalized COVID-19 patients, and to create a comparator arm for a randomized controlled trial evaluating the efficacy and safety of actemra for COVID-19 patients (Genentech)

  • Maternal Marijuana Use During Pregnancy, Marijuana Legalization, and Adverse Obstetrical and Neonatal Outcomes: A 12-year Cohort Study (COVID-19 Revision) (National Institute on Drug Abuse/NIH/DHHS)

  • The impact of COVID-19 pandemic on health status and healthcare utilization among adults with autism spectrum disorders (WITH Foundation (formerly Special Hope Foundation))

  • NA-ACCORD Corona Infectious Virus Epidemiology Team (CIVETs) (National Institute of Allergy and Infectious Diseases/NIH/DHHS)

  • COVID-19 Population Based evaluation of COVID-19 cases (CDC/DHHS)

  • Expanded Access to Convalescent Plasma for the Treatment of Patients with COVID-19

  • Optimizing quality and safety in the era of COVID-19: Virtual care first utilization and outcomes for potentially emergent conditions among KPNC members (Garfield Memorial Fund)

Pending Potential Clinical Studies:

  • Evaluation of antibody/potential immunity status for SARS-CoV-2 using novel assays

  •  Evaluation of ACE Inhibitors and/or Angiotensin II Receptor Use in High-Risk Adults

  • Evaluation of Clinical Outcomes of Adults with Severe COVID-19

​Publications (links added as they are made available on PubMed)

Addressing Problems With Alcohol and Other Substances Among Older Adults During the COVID-19 Pandemic.
Am J Geriatr Psychiatry. 2020 Apr 22.
Satre DD, Hirschtritt ME, Silverberg MJ, Sterling SA.

Characteristics of Hospitalized Adults With COVID-19 in an Integrated Health Care System in California.
JAMA. 2020 Apr 24.
Laura C. Myers, MD, MPH; Stephen M. Parodi, MD; Gabriel J. Escobar, MD; Vincent X. Liu, MD.

COVID-19: Long-term Planning for Procedure-based Specialties During Extended Mitigation and Suppression Strategies.
Gastroenterology. 2020 May 18.
Rouillard S, Liu VX, Corley DA.

COVID-19: What Should Clinicians and Scientists Do and When?.
Gastroenterology. 2020 Mar 19.
Corley DA, Peek RM.

Endometrial Cancer Detection During the Coronavirus Disease 2019 (COVID-19) Pandemic.
Obstetrics and Gynecology 2020 July 21. .
Suh-Burgmann, Elizabeth J., Alavi, Mubarika, Schmittdiel, Julie.

Fever without a source in a young infant due to SARS-CoV-2.
Journal of the Pediatric Infectious Diseases Society. 2020 Apr 22.
Kan MJ, Grant LMC, Muña MA, Greenhow TL.

From Containment to Mitigation of COVID-19 in the US.
JAMA. 2020 Mar 13.
Parodi SM, Liu VX.

Going Viral: Management of IBD in the Era of the COVID-19 Pandemic.
Digestive Disease and Sciences. 2020 May 4.
Gutin LS, Lam AY, Velayos FS, Santos SA.

Incidence, clinical outcomes, and transmission dynamics of hospitalized 2019 coronavirus disease among 9,596,321 individuals residing in California and Washington, United States: a prospective cohort study.
. 2020 April 16.
Lewnard JA, Liu VX, Jackson ML, Schmidt MA, Jewell BL, Flores JP, Chris Jentz, Northrup GR, Mahmud A, Reingold AL, Maya Petersen A, Jewell NP, Young S, Bellows J.

Kaiser Permanente’s System Capabilities to Suppress Covid-19.
NEJM. 2020 June 9.
Parodi, S, Choucair, B, Young, S, Bellows, J, Grossman, D, Liu, VX.

Obesity and Mortality Among Patients Diagnosed With COVID-19: Results From an Integrated Health Care Organization.
Annals Internal Medicine . 2020 Aug 12;M20-3742.
Sara Y. Tartof, Lei Qian, Vennis Hong, Rong Wei, MA; Ron F. Nadjafi, Heidi Fischer, Zhuoxin Li, Sally F. Shaw, Susan L. Caparosa, Claudia L. Nau, Tanmai Saxena, Gunter K. Rieg, Bradley K. Ackerson, Adam L. Sharp, Jacek Skarbinski, Tej K. Naik, and Sameer B. Murali.
doi: 10.7326/M20-3742

Remdesivir for Severe COVID-19 versus a Cohort Receiving Standard of Care.
Clinical Infectious Disease. 2020 Jul 24; ciaa1041.
Susan A Olender, Katherine K Perez, Alan S Go, Bindu Balani, Eboni G Price-Haywood, Nirav S Shah, et.al..
doi: 10.1093/cid/ciaa1041

Telehealth in Oncology During the COVID-19 Outbreak: Bringing the House Call Back Virtually.
Journal of Oncology Practice. 2020 May 4.
Liu R, Sundaresan T, Reed ME, Trosman JR, Weldon CB, Kolevska T.

The Covid-19 Pandemic and the Incidence of Acute Myocardial Infarction.
NEJM. 2020 May 19.
Solomon MD, McNulty EJ, Rana JS, Leong TK, Ambrosy AP, Sidney S, Go AS.