COVID-19 Flatten The Curve

The Permanente Medical Group COVID-19 Clinical Research Coordinating Team (CCRCT) supports evidence-based research in SARS-CoV-2 virus epidemiology including the diagnosis, treatment and prevention of COVID-19 and other clinical outcomes at Kaiser Permanente Northern California.

CCRCT Team Members

Clinical Trials (Active and those with completed enrollment)

  • A Phase 3 Randomized Study to Evaluate the Safety and Antiviral Activity of Remdesivir (GS-5773) in Participants with Severe COVID-19 (Oakland, San Francisco, San Leandro, South San Francisco, Santa Clara, and San Jose Medical Centers) (closed to enrollment) Skarbinski, J

  • A Phase 3 Randomized Study to Evaluate the Safety and Antiviral Activity of Remdesivir (GS-5774) in Participants with Moderate COVID-19 Compared to Standard of Care Treatment (San Francisco, Oakland, San Leandro, South San Francisco, Santa Clara, and San Jose Medical Centers) (closed to enrollment) Skarbinski, J

  • A Phase 3 Randomized, Double-Blind Placebo-Controlled Trial to Evaluate the Efficacy and Safety of Remdesivir (GS-9012) Treatment of COVID-19 in an Outpatient Setting (launching soon at Oakland, San Francisco, San Leandro, South San Francisco, San Jose, Sacramento, South Sacramento, and Vallejo Medical Centers) (open to enrollment) Skarbinski, J

  • A Phase 2 Randomized Single-Blind Study to Evaluate the Activity and Safety of Low Dose Oral Selinexor (KPT-330) in Patients with Severe COVID-19 Infection (XPORT-CoV-1001) (Oakland, San Francisco, and Sacramento Medical Centers) (closed to enrollment) Skarbinski, J

  • Phase 1/2/3, Placebo-controlled, Randomized, Observer-blind, Dose-finding Study to Evaluate the Safety, Tolerability, Immunogenicity, and Efficacy of SARS-CoV-2 RNA Vaccine Candidates Against COVID-19 in Healthy Individuals (closed to enrollment) Klein, N
  • COVID-19 Lattice Swab Evaluation Study (TPMG/DARE-Rapid Analytics Unit) (closed to enrollment)  Corley, D

  • KP NOURISH: Evaluation of the Clinical Utility of Medically-Tailored Meals in Adults with Chronic Conditions (open to enrollment) Go, A
  • A Phase 3, Randomized, Observer-Blind Study to Evlauate the Safety, Tolerability, and Immunogenicity of Multiple Production Lots and Dose Levels of the Vaccine Candidate BNT162b2 Against COVID-19 in Healthy Participants 12 Through 50 Years of Age (closed to enrollment) Klein, N

Active Clinical Studies

  • Characteristics and Clinical Trajectory of COVID-19 Patients Admitted from the Emergency Department (The CREST Network/ DARE-Rapid Analytics Unit) Reed, M. 

  • Risk of COVID-19 pandemic on immunosuppressed populations
    (DARE-Rapid Analytics Unit) Velayos. F. 

  • Decision support and risk prediction for clinicians coping with the COVID-19 pandemic Escobar, G

  • Evaluating the impact of cancer on COVID-19 diagnoses and outcomes
    (DARE-Rapid Analytics Unit) Harzstark, A

  • KPNC mental health services utilization, outcomes, and associated patient characteristics during the COVID-19 pandemic (TPMG/DARE) Erickson-Ridout, K

  • How COVID Changed Our Practice: Telehealth in TPMG Surgical Cancer Care
    (TPMG/DARE-Rapid Analytics Unit) Kuehner, G

  • COVID surveillance (CDC Vaccine Safety Datalink population-based surveillance) (Division of Research) Klein, N

  • The impact of the use of anticoagulants and antiplatelets on the risk of hospitalization and mortality in patients with COVID-19.
    (TPMG/DARE-Rapid Analytics Unit) Pai, A

  • KP Research Bank member survey on  effects of  COVID-19 epidemic (Kaiser Permanente/Division of Research) McGlynn, E

  • A Multi-center, Multi-country Retrospective Cohort Study to Evaluate the Clinical Outcomes in Adults with Severe COVID-19 (Division of Research) Go, A

  • COVID-19-Associated Hospitalization Surveillance in Children and Adults (Division of Research) Skarbinski, J

  • Advancing Understanding of the Impact of Smoking Status on COVID (Division of Research) Young-Wolff, K

  • The impact of COVID-19 pandemic on health status and healthcare utilization among adults with autism spectrum disorders (WITH Foundation (formerly Special Hope Foundation)) Croen, L

  • Innovative Methods to Inform Estimates of Vaccine Effectiveness Using Information on the Epidemiology and Incidence of Influenza and Other Acute Respiratory Illnesses (Division of Research) Klein, N

  • Perinatal COVID-19 Infection National Registry (Med Center Based) Fischer, A

  • Effectiveness and safety of treatments for hospitalized patients with COVID-19 (DOR/Garfield Fund) Liu, V

  • Acute Emergency Care and Outcomes for Stroke, Myocardial Infarction, and Surgery During the COVID-19 Pandemic: Implications for Care Delivery During COVID-19 Recovery Phase and Future Surges (TPMG/DARE, DOR, Garfield Fund) Nguyen-Huynh , M  

  • Epidemiologic Analysis of Chilblains Eruptions at the time of COVID-19 (DARE-Rapid Analytics Unit) McCleskey, P

  • Incidence of outpatient thromboembolism in patients with SARS-CoV-2 infections (DARE-Rapid Analytics Unit) Roubinian, N

  • The Impact of California Shelter-In-Place on Incidence of Gynecologic Emergencies in a Community-Based Population (DARE-Rapid Analytics Unit) Zaritsky, E

  • Examining the "Hidden Epidemic": Consequences of COVID Social Distancing and Health Care System Responses among Patients with Complex Medical and Social Needs (Garfield Memorial Fund) Grant, R

  • COVID-19 pandemic: Impact on colorectal cancer screening and surveillance (Garfield Memorial Fund) Levin, T

  • Identifying Pre-Sepsis Opportunities for Early, Targeted Intervention - COVID19 (PreSepsis-COVID19) (National Institute of General Medical Sciences/NIH/DHHS) Liu, V

  • Comparison of Cross-Sex Hormone Therapies in Relation to Risks of Vascular Events: Characteristics of the COVID-19 Epidemic in Transgender Populations (PCORI) Silverberg, M

  • Utilizing real world data to describe clinical and safety outcomes among hospitalized COVID-19 patients, and to create a comparator arm for a randomized controlled trial evaluating the efficacy and safety of actemra for COVID-19 patients (Genentech) Skarbinski, J

  • Maternal Marijuana Use During Pregnancy, Marijuana Legalization, and Adverse Obstetrical and Neonatal Outcomes: A 12-year Cohort Study (COVID-19 Revision) (National Institute on Drug Abuse/NIH/DHHS) Young-Wolff, K

  • NA-ACCORD Corona Infectious Virus Epidemiology Team (CIVETs) (National Institute of Allergy and Infectious Diseases/NIH/DHHS) Silverberg, M

  • COVID-19 Population Based evaluation of COVID-19 cases (CDC/DHHS) Klein, N

  • Expanded Access to Convalescent Plasma for the Treatment of Patients with COVID-19 Waldron, P

  • Optimizing quality and safety in the era of COVID-19: Virtual care first utilization and outcomes for potentially emergent conditions among KPNC members (Garfield Memorial Fund) Kene, M

  • Rapid Cycle Analysis of COVID-19 vaccine(s) (CDC) Klein, N

  • Assessing the impact of changes in health care utilization during the COVID-19 pandemic on background rate trends and use of telemedicine encounters for vaccine adverse events of special interest.  (CDC) Klein, N

  • Vaccine Enhanced COVID-19 Disease monitoring (CDC) Klein, N

  • SARS-COV=2 vaccine safety evaluation in pregnant women and their infants (CDC) Klein, N

  • COVID-19 Pregnancy and Fetal Death (CDC) Klein, N

  • Assess influenza and COVID-19 vaccination coverage among pregnant women using automated data in VSD. (CDC) Klein, N

​Publications (links added as they are made available on PubMed)

From Containment to Mitigation of COVID-19 in the US.
JAMA. 2020/03/13.
Parodi SM, Liu VX.

COVID-19: What Should Clinicians and Scientists Do and When?.
Gastroenterology. 2020/03/19.
Corley DA, Peek RM.

Incidence, clinical outcomes, and transmission dynamics of hospitalized 2019 coronavirus disease among 9,596,321 individuals residing in California and Washington, United States: a prospective cohort study.
. 2020/04/16.
Lewnard JA, Liu VX, Jackson ML, Schmidt MA, Jewell BL, Flores JP, Chris Jentz, Northrup GR, Mahmud A, Reingold AL, Maya Petersen A, Jewell NP, Young S, Bellows J.

Addressing Problems With Alcohol and Other Substances Among Older Adults During the COVID-19 Pandemic.
Am J Geriatr Psychiatry. 2020/04/22.
Satre DD, Hirschtritt ME, Silverberg MJ, Sterling SA.

Fever without a source in a young infant due to SARS-CoV-2.
Journal of the Pediatric Infectious Diseases Society. 2020/04/22.
Kan MJ, Grant LMC, Muña MA, Greenhow TL.

Characteristics of Hospitalized Adults With COVID-19 in an Integrated Health Care System in California.
JAMA. 2020/04/24.
Laura C. Myers, MD, MPH; Stephen M. Parodi, MD; Gabriel J. Escobar, MD; Vincent X. Liu, MD.

Going Viral: Management of IBD in the Era of the COVID-19 Pandemic.
Digestive Disease and Sciences. 2020/05/04.
Gutin LS, Lam AY, Velayos FS, Santos SA.

Telehealth in Oncology During the COVID-19 Outbreak: Bringing the House Call Back Virtually.
Journal of Oncology Practice. 2020/05/04.
Liu R, Sundaresan T, Reed ME, Trosman JR, Weldon CB, Kolevska T.

COVID-19: Long-term Planning for Procedure-based Specialties During Extended Mitigation and Suppression Strategies.
Gastroenterology. 2020/05/18.
Rouillard S, Liu VX, Corley DA.

The Covid-19 Pandemic and the Incidence of Acute Myocardial Infarction.
NEJM. 2020/05/19.
Solomon MD, McNulty EJ, Rana JS, Leong TK, Ambrosy AP, Sidney S, Go AS.

Kaiser Permanente’s System Capabilities to Suppress Covid-19.
NEJM. 2020/06/09.
Parodi, S, Choucair, B, Young, S, Bellows, J, Grossman, D, Liu, VX.

Endometrial Cancer Detection During the Coronavirus Disease 2019 (COVID-19) Pandemic.
Obstetrics and Gynecology 2020 July 21. 2020/07/20.
Suh-Burgmann, Elizabeth J., Alavi, Mubarika, Schmittdiel, Julie.

Remdesivir for Severe COVID-19 versus a Cohort Receiving Standard of Care.
Clinical Infectious Disease. 2020/07/24.
Susan A Olender, Katherine K Perez, Alan S Go, Bindu Balani, Eboni G Price-Haywood, Nirav S Shah, et.al..

Obesity and Mortality Among Patients Diagnosed With COVID-19: Results From an Integrated Health Care Organization.
Annals Internal Medicine . 2020/08/12.
Sara Y. Tartof, Lei Qian, Vennis Hong, Rong Wei, MA; Ron F. Nadjafi, Heidi Fischer, Zhuoxin Li, Sally F. Shaw, Susan L. Caparosa, Claudia L. Nau, Tanmai Saxena, Gunter K. Rieg, Bradley K. Ackerson, Adam L. Sharp, Jacek Skarbinski, Tej K. Naik, and Sameer B. Murali.

SARS-CoV-2 infection among hospitalized pregnant women: reasons for admission and pregnancy characteristics - Eight U.S. Health Care Centers, March 1 - May 30, 2020.
Morbidity and Mortality Weekly Report. 2020/09/23.
Panagiotakopoulos L, Myers TR, Gee J, Lipkind HS, Kharbanda EO, Ryan DS, Williams JTB, Naleway AL, Klein NP, Hambidge SJ, Jacobsen SJ, Glanz JM, Jackson LA, Shimabukuro TT, Weintraub ES.

Acute Stroke Presentation, Care, and Outcomes in Community Hospitals in Northern California During the COVID-19 Pandemic.
STROKE. 2020/10/01.
Mai N. Nguyen-Huynh, Xian Nan Tang, David R. Vinson, Alexander C. Flint, Janet G. Alexander, Melissa Meighan, Molly Burnett, Stephen Sidney, Jeffrey G. Klingman.