The Cardiology and Cardiac Service Line specialty research group is an integrative group of research-inclined physicians working to assess new evidence to inform and improve clinical care. This research page is a resource to aid in organizing interested clinicians, connect those involved in data-driven inquiry, and plan next steps for data collection that can inform clinical practice change. Some topics of interest include: congestive heart failure, coronary artery disease, valvular heart disease, structural heart disease, preventing chemotherapy-induced cardiac side effects, congenital heart disease, and diet and cardiovascular outcomes, among many others. 

​Physicians Involved in Research

Upcoming Events




American Geriatric Society Annual Scientific

May 13-15, 2021 

Virtual Conference

ACC.21 70th Scientific Sessions

May 15-17, 2021

Virtual Conference


KPNC Cardiovascular Research Symposium
Spring-Summer 2021

​HFSA Annual Scientific Meeting

Sept 10-13, 2021

Aurora, CO


​TCT 2021 Conference

​Oct 22-26, 2021

San Francisco, CA


AHA Scientific Sessions
​Nov 13-15, 2021

Hybrid event

Boston, MA


Ongoing and Completed Cardiology Projects, All Funding Mechanisms

Addressing Age and Blood Pressure  – Utilizing a National Database.
Ashok Krishnaswami. Cardiology. Other. Ongoing.

Changes in weight, lipids, blood pressure, health care utilization and CV outcomes in participants of the Medical Weight Management Program .
Ashok Krishnaswami. Cardiology. Other. Ongoing.

Coronary Artery Risk Development in Young Adults (CARDIA) Study.
Jamal Rana. Cardiology. NIH. Ongoing.

CORVIA 1601 REDUCE LAP HF: A study to evaluate the Corvia Medical, Inc. IASD® System II to REDUCE Elevated Left Atrial Pressure in Patients with Heart Failure.
Ann Sheridan. Cardiology. Industry. Ongoing.

Deprescribing CV and non-CV medications.
Ashok Krishnaswami. Cardiology. Other. Ongoing.

EDWARDS 2017-05 ACTIVE: A trial to assess transcatheter mitral valve repair with Edwards Cardioband System and guideline directed medical therapy (GDMT) compared to GDMT alone in patients with functional mitral regurgitation (FMR) and heart failure.
Andrew Rassi. Cardiology. Industry. Ongoing.

EDWARDS 2018-07 CLASP III: A trial to evaluate safety and effectiveness of transcatheter mitral valve repair with the Edwards PASCAL Transcatheter Mitral Valve Repair System compared to Abbott MitraClip in patients with degenerative mitral regurgitation.
Andrew Rassi. Cardiology. Industry. Ongoing.

EDWARDS EARLY TAVR: Evaluation of Transcatheter Aortic Valve Replacement Compared to Surveillance for Patients with AsYmptomatic Severe Aortic Stenosis: EARLY TAVR trial 2016-07 EARLY TAVR SAPIEN 3 Transcatheter Heart Valve G160259.
Richard Richter. Cardiology. Industry. Ongoing.

Evidence Based Evaluation and Acceptance of Donor Hearts for Transplantation.
Jon Zaroff, Kiran Khush. Cardiology. NIH. Ongoing.

Examination of the Acute Effects of Azithromycin Use on Cardiovascular Mortality, as Compared with Amoxicillin and Levofloxacin.
Jon Zaroff. Cardiology. Pfizer. Ongoing.

Familial hypercholesterolemia II - manuscript.
Richard Birnbaum, Andy Avins. Cardiology. RAU. Ongoing.

GUARD AF: Screening for atrial fibrillation in high risk patients .
Alan Go, Drew Ambrosy, Matt Solomon. Cardiology. Industry. Ongoing.

Hypercoagulability in mechanical circulatory support.
Sirtaz Adatya. Cardiology. Industry. Ongoing.

Implementation of Familial Hypercholoesterolemia and template transition protocol.
Richard Birnbaum, Andy Avins. Cardiology. RAU. Ongoing.

KP Post-PCI Outcomes and Resource Utilization Study, and Development and Validation of a KP Post-PCI Risk Calculator.
Matt Solomon. Cardiology. Industry. Ongoing.

KP Real-world Heart Monitoring StrategY Evaluation, Treatment Patterns and Health Metrics (RHYTHM) Study .
Matt Solomon, Alan Go. Cardiology. Industry. Ongoing.

MEDTRONIC APOLLO: Transcatheter Mitral Valve Replacement with the Medtronic Intrepid™ TMVR System in patients with severe symptomatic mitral regurgitation.
Jacob Mishell. Cardiology. Industry. Ongoing.

MITRALIGN CLPR- 010 SCOUT: Early Feasibility Of The Mitralign Percutaneous Tricuspid Valve Annuloplasty System (Ptvas) For Symptomatic Chronic Functional Tricuspid Regurgitation CLPR-010.
Andrew Rassi. Cardiology. Industry. Ongoing.

Multicenter Arteriovenous malformation Research Study (MARS) extension.
Jon Zaroff, Helen Kim. Cardiology. NIH. Ongoing.

PIONEER-HF: A large, multi-center randomized clinical trial of sacubitril- valsartan versus enalapril in heart failure.
Drew Ambrosy. Cardiology. Industry. Ongoing.

Pulse Pressure, Treatment Intensity in Participants of the SPRINT trial.
Ashok Krishnaswami. Cardiology. Other. Ongoing.

Systematic Review of the role of age in cardiac imaging.
Ashok Krishnaswami. Cardiology. Other. Ongoing.

The PERFUSE SCAD Registry .
Sahar Naderi. Cardiology. Other. Ongoing.

Transcatheter aortic valve replacement – Personalizing risk for quality of life, developing complications, total mortality, and utilization (TAVR - PREDICT) Study.
Ed McNulty, Alan Go. Cardiology. DSRP. Ongoing.

Use of Elixhauser Comorbidity Index in risk stratifying participants referred for Permanent Pacemaker placement.
Ashok Krishnaswami. Cardiology. Other. Ongoing.

Adherence to Guideline Recommendations for Secondary Prevention and Mortality after Acute MI .
Matt Solomon, Alan Go. Cardiology. Industry. Completed.

Assessing Glycosylated Hemoglobin (HbA1c) Thresholds for Development of Cardiovascular Disease by Racial-Ethnic Groups.
Seema Pursani. Cardiology. CB. Completed.

BSC S2073 EVOLVE: Study assessing safety of 3-month dual antiplatelet therapy (DAPT) in subjects at high risk for bleeding undergoing percutaneous coronary intervention (PCI) with the SYNERGYTM Everolimus-Eluting Platinum Chromium Coronary Stent System.
Andrew Rassi. Cardiology. Industry. Completed.

CABG vs PCI in Older Acute Coronary Syndrome (ACS) patients: Impact of revascularization strategy on outcomes.
Ahmed Shah. Cardiology. CB. Completed.

Clopidogrel Duration after Chronic Total Occlusion Percutaneous Coronary Intervention.
Amit Sachdeva. Cardiology. CB. Completed.

Development of chronic thromboembolic pulmonary hypertension after acute pulmonary embolism.
Choon Goh. Cardiology. CB. Completed.

Duration of thienopyridine therapy and outcomes after PCI for chronic total occlusions.
Amit Sachdeva. Cardiology. CB. Completed.

EDWARDS 2015-08 AVIV: A Prospective, Single-Arm, Multicenter Study to Investigate the Safety and Effectiveness of SAPIEN 3 Transcatheter Heart Valve Implantation in Patients With a Failing Aortic Bioprosthetic Valve.
Edward McNulty. Cardiology. Industry. Completed.

EDWARDS 2015-08 P3: A study to establish the safety and Effectiveness of the Sapien 3 Transcatheter Heart Valve in low risk patients who have severe, calcific, aortic stenosis requiring Aortic Valve Replacement.
Edward McNulty. Cardiology. Industry. Completed.

Epidemiology and Outcomes for Thoracic Aortic Aneurysms and Acute Aortic Dissections.
Matt Solomon. Cardiology. CB. Completed.

EVALVE 11-512- COAPT: A Clinical Evaluation of the Safety and Effectiveness of the MitraClip® System for the Treatment of Functional Mitral Regurgitation in Symptomatic Heart Failure Subjects.
Jacob Mishell. Cardiology. Industry. Completed.

Familial hypercholesterolemia.
Richard Birnbaum, Andy Avins. Cardiology. RAU. Completed.

Heart failure readmission intervention.
Keane Lee, Alan Go. Cardiology. DSRP. Completed.

Identification and management of familial hypercholesterolemia in an integrated health care delivery system..
Richard Birnbaum. Cardiology. RAU. Completed.

Interaction Between Choice of Anticoagulation, Antiplatelet Therapy and Access Site on Mortality and Bleeding after Percutaneous Coronary Intervention: Insights from the California National Cardiovascular Data Registry ( NCDR) and KP PCI Registry.
Femi Philip. Cardiology. CB. Completed.

Management and outcomes of patients with valvular heart disease.
Matt Solomon, Alan Go. Cardiology. PRP. Completed.

Severe Hypoglycemia and Risk of Atherosclerotic Cardiovascular Disease (ASCVD) in Patients with Diabetes.
Jamal Rana. Cardiology. CB. Completed.

Status and impact of Ideal Cardiovascular Health, as defined by American Heart Association, among KPNC population.
Jamal Rana. Cardiology. CB. Completed.

Ticagrelor vs. Clopidogrel in Acute Coronary Syndromes: A Real-World, Community-Based Comparison of Ischemic and Bleeding Outcomes.
Amit Sachdeva. Cardiology. CB. Completed.

Use and outcomes of CT angiography.
Jamal Rana, Alan Go. Cardiology. DSRP. Completed.

Publications (Update in progress - see 2019 Newsletter)

Applying data science approaches to identify frequent flyers in heart failure: rise of the machines.
European journal of heart failure. 2/7/2019.
Ambrosy AP, Lee KK.

Associations of Accelerometer-Measured Sedentary Time and Physical Activity With Prospectively Assessed Cardiometabolic Risk Factors: The CARDIA Study.
Journal of the American Heart Association. 1/8/2019.
Whitaker KM, Pettee Gabriel K, Buman MP, Pereira MA, Jacobs DR, Reis JP, Gibbs BB, Carnethon MR, Staudenmayer J, Sidney S, Sternfeld B.

Associations of Unhealthy Food Environment With the Development of Coronary Artery Calcification: The CARDIA Study.
Journal of the American Heart Association. 2/19/2019.
Kelman J, Pool LR, Gordon-Larsen P, Carr JJ, Terry JG, Rana JS, Kershaw KN.

Blood Pressure Control and Cardiovascular Outcomes in Patients With Atrial Fibrillation (From the ORBIT-AF Registry).
The American journal of cardiology. 2/23/2019.
Vemulapalli S, Inohara T, Kim S, Thomas L, Piccini JP, Patel MR, Chang P, Fonarow GC, Ezekowitz MD, Hylek E, Go AS, Kowey PR, Mahaffey KW, Gersh BJ, Peterson ED.

Changes in physical and mental health are associated with cardiovascular disease incidence in postmenopausal women.
Age and ageing. 2/11/2019.
Saquib N, Brunner R, Desai M, Kroenke C, Martin LW, Daviglus M, Allen NB, Robinson J, Tindle H, Stefanick ML.

Health Status After Transcatheter Mitral-Valve Repair in Heart Failure and Secondary Mitral Regurgitation: COAPT Trial.
Journal of the American College of Cardiology. 3/4/2019.
Arnold SV, Chinnakondepalli KM, Spertus JA, Magnuson EA, Baron SJ, Kar S, Lim DS, Mishell JM, Abraham WT, Lindenfeld JA, Mack MJ, Stone GW, Cohen DJ, COAPT Investigators.

Improving first shock success in patients with atrial fibrillation undergoing electrical cardioversion.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 3/20/2019.
Vinson DR, Isaacs DJ, Othieno AA, Liu TI.

Kidney function, proteinuria and breast arterial calcification in women without clinical cardiovascular disease: The MINERVA study.
PloS one. 2019.
Parikh RV, Iribarren C, Lee C, Levine-Hall T, Tan TC, Sanchez G, Ding H, Bidgoli FA, Molloi S, Go AS.

Lipids, Apolipoproteins, and Risk of Atherosclerotic Cardiovascular Disease in Persons With CKD.
American journal of kidney diseases : the official journal of the National Kidney Foundation. 1/24/2019.
Bajaj A, Xie D, Cedillo-Couvert E, Charleston J, Chen J, Deo R, Feldman HI, Go AS, He J, Horwitz E, Kallem R, Rahman M, Weir MR, Anderson AH, Rader DJ, CRIC Study Investigators.

Longitudinal exploration of in situ mock code events and the performance of cardiac arrest skills.
BMJ simulation & technology enhanced learning. 2019-01.
Clarke SO, Julie IM, Yao AP, Bang H, Barton JD, Alsomali SM, Kiefer MV, Al Khulaif AH, Aljahany M, Venugopal S, Bair AE.

Lower risk of venous thromboembolism in multiple Asian ethnic groups.
Preventive medicine reports. 2019-03.
Nicole Tran H, Klatsky AL.

Natriuretic peptides as a surrogate endpoint in clinical trials - a riddle wrapped in an enigma.
European journal of heart failure. 3/27/2019.
Hardwick AB, Ambrosy AP.

Predictive Model for High-Risk Coronary Artery Disease.
Circulation. Cardiovascular imaging. 2019-02.
Jang JJ, Bhapkar M, Coles A, Vemulapalli S, Fordyce CB, Lee KL, Udelson JE, Hoffmann U, Tardif JC, Jones WS, Mark DB, Sorrell VL, Espinoza A, Douglas PS, Patel MR, PROMISE Investigators.

Risk factors for medication non-adherence among atrial fibrillation patients.
BMC cardiovascular disorders. 2/11/2019.
Reading SR, Black MH, Singer DE, Go AS, Fang MC, Udaltsova N, Harrison TN, Wei RX, Liu IA, Reynolds K, ATRIA-CVRN Investigators.

Sex-specific Association of Matrix Metalloproteinases with Secondary Injury and Outcomes after Intracerebral Hemorrhage.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 3/25/2019.
Howe MD, Furr JW, Zhu L, Edwards NJ, McCullough LD, Gonzales NR.

Trimethylamine N-oxide and risk of heart failure progression: marker or mediator of disease.
European journal of heart failure. 1/9/2019.
Chioncel O, Ambrosy AP.

2019 American College of Cardiology Abstracts

Prior Exposure to a Conventional Renin-Angiotensin System Antagonist and Angiotensin Receptor-Neprilysin Inhibition in Acute Decompensated Heart Failure: A Prespecified Subgroup Analysis of the PIONEER-HF Trial

Andrew P. Ambrosy, MD; Adam D. DeVore, MD; David A. Morrow, MD; Eugene Braunwald, MD; Carol I. Duffy, DO; Kevin McCague, MS; Ricardo Rocha, MD; Eric J. Velazquez, MD

Transcatheter Device Closure of a Post-Infarction Basilar Ventricular Septal Rupture in a Patient Presenting With Cardiogenic Shock

Harshith R. Avula, MD, Andrew Rassi, MD, Stephanie Chen, MD, Liviu Klein, MD, MS, Jonathan Zaroff, MD

Identification and Management of Familial Hypercholesterolemia in an Integrated Health Care Delivery System

Richard A. Birnbaum, MD, Brandon H. Horton, Leslie Manace Brenman, MD, Andrew L. Avins

Spontaneous Coronary Artery Dissection and incident Ventricular Arrhythmias. Frequency, clinical characteristics, and outcomes

Stephanie Chen, MD, Harshith R Avula, MD, Andrew P Ambrosy, MD, Robert Lundstrom, MD, Sahar Naderi, MD

AuInitiation of Angiotensin-Neprilysin Inhibition after Acute Decompensated Heart Failure: Results of the Open-Label Extension of the PIONEER-HF Trial (Late-Breaking Clinical Trial Session)

Adam D. DeVore, MD; Eugene Braunwald, MD; David A. Morrow, MD; Carol I. Duffy, DO; Andrew P. Ambrosy, MD; Kevin McCague, MS; Ricardo Rocha, MD; Eric J. Velazquez, MD

Association of Elixhauser Comorbidity Index to 1-Year Mortality in Older Adults After Permanent Pacemaker Implantation

Ashok Krishnaswami, MD, MAS ;Taylor Liu, MD, PhD ; Wei Wang, PhD, MS ; Jessica Harris, MS, RD; Elizabeth W. Paxton, MA; Frederick W. Masoudi, MD

Longitudinal Change and Fluctuation in QT and Cardiovascular Outcomes – Insights from a Large Integrated Healthcare Delivery System

Neha Mantri MD, Meng Lu MS, Carlos Iribarren, MD

Diagnostic Evaluation of a Right Atrial Mass with Multimodality Imaging and Endomyocardial Biopsy: A Clinical Conundrum

Neha Mantri MD, Ahmad Sheikh MD, Andrew Ambrosy MD, Jennifer Ting MD, Robert Lundstrom MD

Associations of Bleeding and Ischemic Outcomes with Duration of Thienopyridine Therapy after Percutaneous Coronary Intervention for Coronary Chronic Total Occlusion

Amit Sachdeva, MD, Yun-Yi Hung PhD, MPH, Edward J. McNulty, MD

Re-Evaluation of Race and Ethnicity with Adverse Outcomes in Heart Failure

Samuel T. Savitz PhD, Jamal S. Rana MD, Keane Lee MD, Thomas Leong MPH, Sue Hee Sung MPH, Grace Tabada MPH, Alan S. Go MD

Development and Validation of Models to Predict Long-Term Outcomes and Resource Utilization After Percutaneous Coronary Intervention

Matthew D. Solomon, MD, PhD, Thomas Leong, MPH, Sue Hee Sung MPH, Catherine Lee, PhD, Samuel T. Savitz, PhD, Jamal S. Rana, MD, PhD, Edward J. McNulty, MD, Alan S. Go, MD

2019 American Heart Association Abstracts

Functional Iron Deficiency Is Independently Associated With Increased Risk Of Morbidity And Mortality In Older Adults

Ambrosy AP, Tabada GH, Gurwitz J, Artz A, Schrier S, Rao SV, Reynolds K, Smith DH, Peterson PN, Sung SH, Cohen HJ, Go, AS.

Human Immunodeficiency Virus Infection and Risks of Death and Heart Failure Hospitalization in Adults with Incident Heart Failure.

Avula HR, Ambrosy AP, Silverberg MJ, Reynolds K, Towner WJ, Hechter RC, Horberg M, Vupputuri S, Leong TK, Leyden WA, Harrison TN, Lee KK, Sung SH, Go AS.

Atrial Fibrillation and Stroke: Causal Relationship or Risk Marker?

Go AS.

The Influence of Race/Ethnicity on Burden of Atrial Fibrillation: The KP RHYTHM Study

Yang JR, Reynolds K, Gupta, N, Lenane J, Garcia, EA, Sung SH, Harrison TN, Solomon MD, Go AS.

Improving Cardiovascular Risk Prediction In Asian Subgroups

Parikh R, Rana JS, Tan TC, Pursnani SK, Mantri NM, Go AS.

Using Natural Language Processing to Accurately Identify Aortic Stenosis in a Large, Integrated Healthcare Delivery System.  

Solomon MD, Tabada G, Allen A, Sung SH, Go AS.