COVID-19 Flatten The Curve

The Permanente Medical Group COVID-19 Clinical Research Coordinating Team (CCRCT) supports evidence-based research in SARS-CoV-2 virus epidemiology including the diagnosis, treatment and prevention of COVID-19 and other clinical outcomes at Kaiser Permanente Northern California.

CCRCT Team Members

Clinical Trials (Active and those with completed enrollment)

  • A Phase 3 Randomized Study to Evaluate the Safety and Antiviral Activity of Remdesivir (GS-5773) in Participants with Severe COVID-19 (Oakland, San Francisco, San Leandro, South San Francisco, Santa Clara, and San Jose Medical Centers) (closed to enrollment) Skarbinski, J

  • A Phase 3 Randomized Study to Evaluate the Safety and Antiviral Activity of Remdesivir (GS-5774) in Participants with Moderate COVID-19 Compared to Standard of Care Treatment (San Francisco, Oakland, San Leandro, South San Francisco, Santa Clara, and San Jose Medical Centers) (closed to enrollment) Skarbinski, J

  • A Phase 3 Randomized, Double-Blind Placebo-Controlled Trial to Evaluate the Efficacy and Safety of Remdesivir (GS-9012) Treatment of COVID-19 in an Outpatient Setting (closed to enrollment) Skarbinski, J

  • A Phase 2 Randomized Single-Blind Study to Evaluate the Activity and Safety of Low Dose Oral Selinexor (KPT-330) in Patients with Severe COVID-19 Infection (XPORT-CoV-1001) (Oakland, San Francisco, and Sacramento Medical Centers) (closed to enrollment) Skarbinski, J

  • Phase 1/2/3, Placebo-controlled, Randomized, Observer-blind, Dose-finding Study to Evaluate the Safety, Tolerability, Immunogenicity, and Efficacy of SARS-CoV-2 RNA Vaccine Candidates Against COVID-19 in Healthy Individuals (closed to enrollment) Klein, N
  • COVID-19 Lattice Swab Evaluation Study (TPMG/DARE-Rapid Analytics Unit) (closed to enrollment)  Corley, D

  • KP NOURISH: Evaluation of the Clinical Utility of Medically-Tailored Meals in Adults with Chronic Conditions (closed to enrollment) Go, A
  • A Phase 3, Randomized, Observer-Blind Study to Evlauate the Safety, Tolerability, and Immunogenicity of Multiple Production Lots and Dose Levels of the Vaccine Candidate BNT162b2 Against COVID-19 in Healthy Participants 12 Through 50 Years of Age (closed to enrollment) Klein, N
  • CISA COVID-19 Pediatric Study Kaiser (CDC/DHHS) (closed to enrollment) Klein, N 
  • A multicenter, randomized, placebo-controlled, pragmatic Phase 3 study investigating the efficacy and safety of rivaroxaban to reduce the risk of major venous and arterial thrombotic events, hospitalization and death in medically ill outpatients with acute, symptomatic COVID-19 infection (PREVENT HD) (open to enrollment) Go, A
  • A Phase 1, Open-Label Dose-Finding Study To Evaluate Safety, Tolerability, and Immunogenicity and Phase 2/3 Placebo Controlled, Observer-Blinded Safety, Tolerability, and Immunogenicity Study of SARS-CoV-2 RNA Vaccine Candidate Against COVID-19 In Healthy Children <12 Years of Age (Closed to enrollment) N. Klein
  • A Phase 3 Master Protocol to Evaluate Additional Dose(s) of BNT162B2 in Health Individuals Previously Vaccinated with BNT162B2. N Klein (closed to enrollment)

Active Clinical Studies

  • Characteristics and Clinical Trajectory of COVID-19 Patients Admitted from the Emergency Department (The CREST Network/ DARE-Rapid Analytics Unit) Reed, M. 

  • Risk of COVID-19 pandemic on immunosuppressed populations
    (DARE-Rapid Analytics Unit) Velayos. F. 

  • Decision support and risk prediction for clinicians coping with the COVID-19 pandemic Escobar, G

  • Evaluating the impact of cancer on COVID-19 diagnoses and outcomes
    (DARE-Rapid Analytics Unit) Harzstark, A

  • KPNC mental health services utilization, outcomes, and associated patient characteristics during the COVID-19 pandemic (TPMG/DARE) Erickson-Ridout, K

  • How COVID Changed Our Practice: Telehealth in TPMG Surgical Cancer Care
    (TPMG/DARE-Rapid Analytics Unit) Kuehner, G

  • COVID surveillance (CDC Vaccine Safety Datalink population-based surveillance) (Division of Research) Klein, N

  • The impact of the use of anticoagulants and antiplatelets on the risk of hospitalization and mortality in patients with COVID-19.
    (TPMG/DARE-Rapid Analytics Unit) Pai, A

  • KP Research Bank member survey on  effects of  COVID-19 epidemic (Kaiser Permanente/Division of Research) McGlynn, E

  • A Multi-center, Multi-country Retrospective Cohort Study to Evaluate the Clinical Outcomes in Adults with Severe COVID-19 (Division of Research) Go, A

  • COVID-19-Associated Hospitalization Surveillance in Children and Adults (Division of Research) Skarbinski, J

  • Advancing Understanding of the Impact of Smoking Status on COVID (Division of Research) Young-Wolff, K

  • The impact of COVID-19 pandemic on health status and healthcare utilization among adults with autism spectrum disorders (WITH Foundation (formerly Special Hope Foundation)) Croen, L

  • Innovative Methods to Inform Estimates of Vaccine Effectiveness Using Information on the Epidemiology and Incidence of Influenza and Other Acute Respiratory Illnesses (Division of Research) Klein, N

  • Perinatal COVID-19 Infection National Registry (Med Center Based) Fischer, A

  • Effectiveness and safety of treatments for hospitalized patients with COVID-19 (DOR/Garfield Fund) Liu, V

  • Acute Emergency Care and Outcomes for Stroke, Myocardial Infarction, and Surgery During the COVID-19 Pandemic: Implications for Care Delivery During COVID-19 Recovery Phase and Future Surges (TPMG/DARE, DOR, Garfield Fund) Nguyen-Huynh , M  

  • Epidemiologic Analysis of Chilblains Eruptions at the time of COVID-19 (DARE-Rapid Analytics Unit) McCleskey, P

  • Incidence of outpatient thromboembolism in patients with SARS-CoV-2 infections (DARE-Rapid Analytics Unit) Roubinian, N

  • The Impact of California Shelter-In-Place on Incidence of Gynecologic Emergencies in a Community-Based Population (DARE-Rapid Analytics Unit) Zaritsky, E

  • Examining the "Hidden Epidemic": Consequences of COVID Social Distancing and Health Care System Responses among Patients with Complex Medical and Social Needs (Garfield Memorial Fund) Grant, R

  • COVID-19 pandemic: Impact on colorectal cancer screening and surveillance (Garfield Memorial Fund) Levin, T

  • Identifying Pre-Sepsis Opportunities for Early, Targeted Intervention - COVID19 (PreSepsis-COVID19) (National Institute of General Medical Sciences/NIH/DHHS) Liu, V

  • Comparison of Cross-Sex Hormone Therapies in Relation to Risks of Vascular Events: Characteristics of the COVID-19 Epidemic in Transgender Populations (PCORI) Silverberg, M

  • Utilizing real world data to describe clinical and safety outcomes among hospitalized COVID-19 patients, and to create a comparator arm for a randomized controlled trial evaluating the efficacy and safety of actemra for COVID-19 patients (Genentech) Skarbinski, J

  • Maternal Marijuana Use During Pregnancy, Marijuana Legalization, and Adverse Obstetrical and Neonatal Outcomes: A 12-year Cohort Study (COVID-19 Revision) (National Institute on Drug Abuse/NIH/DHHS) Young-Wolff, K

  • NA-ACCORD Corona Infectious Virus Epidemiology Team (CIVETs) (National Institute of Allergy and Infectious Diseases/NIH/DHHS) Silverberg, M

  • COVID-19 Population Based evaluation of COVID-19 cases (CDC/DHHS) Klein, N

  • Expanded Access to Convalescent Plasma for the Treatment of Patients with COVID-19 Waldron, P

  • Optimizing quality and safety in the era of COVID-19: Virtual care first utilization and outcomes for potentially emergent conditions among KPNC members (Garfield Memorial Fund) Kene, M

  • Rapid Cycle Analysis of COVID-19 vaccine(s) (CDC) Klein, N

  • Assessing the impact of changes in health care utilization during the COVID-19 pandemic on background rate trends and use of telemedicine encounters for vaccine adverse events of special interest.  (CDC) Klein, N

  • Vaccine Enhanced COVID-19 Disease monitoring (CDC) Klein, N

  • SARS-COV-2 vaccine safety evaluation in pregnant women and their infants (CDC) Klein, N

  • COVID-19 Pregnancy and Fetal Death (CDC) Klein, N

  • Assess influenza and COVID-19 vaccination coverage among pregnant women using automated data in VSD. (CDC) Klein, N

  • COVID-19 Infrastructure and Activities Vaccine Safety Datalink Project, VSD COVID-19 Infrastructure and Participating Activities (Centers for Disease Control and Prevention) Klein, N
  • The Epidemiology of SARS-CoV-2 in Pregnancy and Infancy (ESPI) Network:ESPI-Electronic Cohort (CDC) Li, De-Kun
  • COVID-19-Related Enhancements to "Evaluation of complex interventions on
    drug (re)fill behavior using electronic healthcare data" (Administrative
    Supplement) (PCORI) Neugebauer, R
  • Tools for Outpatient and Population Management of SARS COV-2 Infection (TOPS2) (TPMG Delivery Science Projects Program) Escobar, G
  • Convalescent COVID-19 Plasma Expanded Access Program (Kaiser Foundation Hospitals) Go, A

  • COVID-19 and Venous Thromboembolism Risk (Administrative Supplement)(Patient-Centered Outcomes Research Institute (PCORI)) Go, A
  • Innovative Methods to Inform Estimates of Vaccine Effectiveness
    Using Information on the Epidemiology and Incidence of Influenza and Other
    Acute Respiratory Illnesses (CDC) Klein, N
  • SARS-CoV-2 Serological Antibody Testing for Disease Surveillance and
    Clinical Use (NIH) Skarbinski, J

  • Descriptive Analysis of COPD patients with COVID-19 (Boehringer Ingelheim
    Pharmaceuticals, Inc.) Myers, L

  • Smoking and COVID-19 onset and severity in a US integrated healthcare
    delivery system (Tobacco-Related Disease Research Program) Piazza, K
  • Optimizing quality and safety in the era of COVID-19: Virtual care first
    utilization and outcomes for potentially emergent conditions among KPNC
    members (Garfield Memorial Fund) Mamata, K
  • COVID-19 Pandemic: Impact on Colorectal Cancer Screening and
    Adenoma Surveillance Outcomes (PICASO) (Garfield Memorial Fund) Levin, TR
  • COVID-19 related changes in health care delivery and health outcomes among pregnant women and their newborns (The Permanente Medical Group) Ferrara, A
  • Cross-Cohort Collaboration on COVID-19 Research (4CR) (National Heart, Lung, and Blood Institute) Sydney, S

  • Smoking and COVID-19 Onset and Severity in a US Integrated Health Care Delivery System (Tobacco-Related Disease Research Program) Young-Wolf, K