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Studies

To explore Kaiser Permanente Northern California studies search keywords, find by program, find by specialty or find by study status.

Cardiology

[2022 Continued Funding] Objective cardiac testing following emergency department evaluations for chest pain: associations between referral for non-invasive cardiac testing and 2-year adverse outcomes.

Dustin Mark | Community Health Completed

A Pragmatic Randomized Controlled Trial of a Bundled, Pharmicist-Led Hyper-polypharmacy Deprescribing Intervention

Lynn Deguzman, Maisha Draves, Lisa Herrinton | Other

Accuracy of Prenatal Detection of Clinically Significant Congenital Heart Disease Among Still- and Live-Births at Kaiser Permanente Northern California

Kavin Desai, Lisa Herrinton | Rapid Analytics Unit | View Summary Completed

Acute Emergency Care and Outcomes for Stroke, Myocardial Infarction, and Surgery During the COVID-19 Pandemic in Kaiser Permanente Northern California: Implications for Care Delivery During COVID-19 Recovery Phase and Future Surges

Mai Nguyen-Huynh, Matthew Solomon, David Vinson, Robert Chang | Other Ongoing

Addressing Age and Blood Pressure – Utilizing a National Database

Ashok Krishnaswami | Other Ongoing

Adherence to Guideline Recommendations for Secondary Prevention and Mortality after Acute MI

Matt Solomon, Alan Go | Industry Completed

Assessing Glycosylated Hemoglobin (HbA1c) Thresholds for Development of Cardiovascular Disease by Racial-Ethnic Groups

Seema Pursani | Community Health Completed

Assessing Syndemics of Cardiovascular Disease in People with and without HIV

Michael Silverberg | NIH Ongoing

Assessing the impact of the COVID-19 pandemic on glycemic control and covid-19 infection in diabetic patients

Seema Pursnani | Other

Association of multimorbidity in older adults after permanent pacemaker placement

Ashok Krishnaswami | Unfunded

Atherosclerotic cardiovascular disease risk in South Asians by statin use

Seema Pursnani | Other

BSC S2073 EVOLVE: Study assessing safety of 3-month dual antiplatelet therapy (DAPT) in subjects at high risk for bleeding undergoing percutaneous coronary intervention (PCI) with the SYNERGYTM Everolimus-Eluting Platinum Chromium Coronary Stent System

Andrew Rassi | Industry Completed

CABG vs PCI in Older Acute Coronary Syndrome (ACS) patients: Impact of revascularization strategy on outcomes

Ahmed Shah | Community Health Completed

Changes in weight, lipids, blood pressure, health care utilization and CV outcomes in participants of the Medical Weight Management Program

Ashok Krishnaswami | Other Ongoing

Characterizing the development of cardiovascular disease in women after adverse pregnancy outcomes.

Victoria Woo | Community Health Completed

Characterizing the development of cardiovascular disease in women after adverse pregnancy outcomes.

Victoria Woo | Community Health Completed

Clinical Characteristics of COVID-19 in Solid Organ Transplant Recipients

Dana Weisshaar | Other

Clinical Characteristics, Periprocedural Complications, and Outcomes of Patients with Severe Aortic Stenosis Undergoing Elective versus Urgent/Emergent Transcatheter Aortic Valve Replacement within an Integrated Health Care Delivery System

Mishell, Jacob MD | Community Health Completed

Clopidogrel Duration after Chronic Total Occlusion Percutaneous Coronary Intervention

Amit Sachdeva | Community Health Completed

Comparative Assessment of Coronary Revascularization Strategies on Dementia Incidence in Older Adults with an Acute Coronary Syndrome

Ashok Krishnaswami | Community Health Ongoing

Comparison of high risk elective percutaneous coronary intervention in CV surgery back-up sites versus non-CV surgical back-up sites

Shah, Ahmed MD | Community Health Completed

Comprehensive assessment of harm and benefit in SPRINT

Ashok Krishnaswami | Other

Contemporary Risk Stratification in Adults with Heart Failure and Reduced Ejection Fraction

Adatya, Sirtaz, MD | Community Health Completed

Coronary Artery Risk Development in Young Adults (CARDIA) Study

Jamal Rana | NIH Ongoing

CORVIA 1601 REDUCE LAP HF: A study to evaluate the Corvia Medical, Inc. IASD® System II to REDUCE Elevated Left Atrial Pressure in Patients with Heart Failure

Ann Sheridan | Industry Ongoing

Deprescribing CV and non-CV medications

Ashok Krishnaswami | Other Ongoing

Development of chronic thromboembolic pulmonary hypertension after acute pulmonary embolism

Choon Goh | Community Health Completed

Disparities in Redidual Risk in Patients Reveiving Statins for Primary or Secondary Prevention at an Integrated Health Care Delviery System (KP Reach)

Andrew Ambrosy | Industry

Duration of Dual Antiplatelet Therapy After Percutaneous Coronary Intervention for Chronic Total Occlusion

Amit Sachdeva | Community Health

Duration of thienopyridine therapy and outcomes after PCI for chronic total occlusions

Amit Sachdeva | Community Health Completed

EDWARDS 2015-08 AVIV: A Prospective, Single-Arm, Multicenter Study to Investigate the Safety and Effectiveness of SAPIEN 3 Transcatheter Heart Valve Implantation in Patients With a Failing Aortic Bioprosthetic Valve

Edward McNulty | Industry Completed

EDWARDS 2015-08 P3: A study to establish the safety and Effectiveness of the Sapien 3 Transcatheter Heart Valve in low risk patients who have severe, calcific, aortic stenosis requiring Aortic Valve Replacement

Edward McNulty | Industry Completed

EDWARDS 2017-05 ACTIVE: A trial to assess transcatheter mitral valve repair with Edwards Cardioband System and guideline directed medical therapy (GDMT) compared to GDMT alone in patients with functional mitral regurgitation (FMR) and heart failure

Andrew Rassi | Industry Ongoing

EDWARDS 2018-07 CLASP III: A trial to evaluate safety and effectiveness of transcatheter mitral valve repair with the Edwards PASCAL Transcatheter Mitral Valve Repair System compared to Abbott MitraClip in patients with degenerative mitral regurgitation

Andrew Rassi | Industry Ongoing

EDWARDS EARLY TAVR: Evaluation of Transcatheter Aortic Valve Replacement Compared to Surveillance for Patients with AsYmptomatic Severe Aortic Stenosis: EARLY TAVR trial 2016-07 EARLY TAVR SAPIEN 3 Transcatheter Heart Valve G160259

Richard Richter | Industry Ongoing

Effect of lipid (LDL) monitoring on patients’ statin adherence and physician practice behaviors after an ASCVD event.

Rana, Jamal MD PhD | Community Health Completed

Effectiveness of Care Processes Recommended to Improve Perioperative Cardiovascular Risk Management for Noncardiac Surgery

Lisa Herrinton | Other

Epidemiology and Outcomes for Patients with Bicuspid Aortic Valve

Matthew Solomon | Community Health Completed

Epidemiology and Outcomes for Thoracic Aortic Aneurysms and Acute Aortic Dissections

Matt Solomon | Community Health Completed

Evaluating Inpatient and Outpatient Encounters Within a Learning and Integrated Health Care Delivery Organization Due to Worsening Heart Failure

Andrew Ambrosy, Alan Go | Industry

Evaluating the relationship between coronary artery calcium score and cardiovascular events by race/ ethnicity in a large, diverse integrated healthcare system

Seema Pursnani | Community Health Ongoing

EVALVE 11-512- COAPT: A Clinical Evaluation of the Safety and Effectiveness of the MitraClip® System for the Treatment of Functional Mitral Regurgitation in Symptomatic Heart Failure Subjects

Jacob Mishell | Industry Completed

Evidence Based Evaluation and Acceptance of Donor Hearts for Transplantation

Jon Zaroff, Kiran Khush | NIH Ongoing

Examination of the Acute Effects of Azithromycin Use on Cardiovascular Mortality, as Compared with Amoxicillin and Levofloxacin

Jon Zaroff | Industry Ongoing

Familial hypercholesterolemia II – manuscript

Richard Birnbaum, Andy Avins | Rapid Analytics Unit

GUARD AF: Screening for atrial fibrillation in high risk patients

Alan Go, Drew Ambrosy, Matt Solomon | Industry Ongoing

Healthy Eating as a Means for Active Living in Heart Failure (HEAL-HF)) Study

Andrew Ambrosy, Alan Gl, Nancy Gordan | Community Health

Heart Failure Epidemiology and Risk Prediction of Outcomes In Adults with Chronic Kidney Disease (HEROIC)

Andrew Ambrosy | Community Health Ongoing

Heart failure readmission intervention

Keane Lee, Alan Go | Delivery Science Grants Program Completed

HIV Infection and Risks of Morbidity and Death in Adults with Incident Heart Failure

Alan Go, Michael Siverberg | Other

HIV Risk of Developing Heart Failure by Age, Gender and Race/Ethnicity: The HIV HEART Study

Alan Go, Michael Siverberg | Other

Hypercoagulability in mechanical circulatory support

Sirtaz Adatya | Industry Ongoing

Identification and management of familial hypercholesterolemia in an integrated health care delivery system.

Richard Birnbaum | Rapid Analytics Unit | View Summary Completed

Impact of wildfire air pollution on rates of cardiovascular events and mortality

Stacey Alexeeff | Community Health Completed

Implementation of Familial Hypercholesterolemia and template transition protocol

Richard Birnbaum, Andy Avins | Rapid Analytics Unit Completed

Improved Outcomes with Home-Based Cardiac Rehabilitation-Experience from a Large Integrated Heathcare System

Uma Vadlakonda, Mary Reed | Rapid Analytics Unit | View Summary Completed

Improving Care by Defining the Role of ElectroNic HealTh Record-Based Alerts In a Fully Integrated Health Care Delivery SYstem for Worsening Heart Failure (IDENTIFY-WHF)

Drew Ambrosy | Delivery Science Grants Program Ongoing

Improving quality by TARGETing LDL using a systems-based approach to evaluate our current performance (TARGET-LDL)

Adam Rogers, Carlos Iribarren | Delivery Science Grants Program | View Summary Completed

Improving Risk Stratification for Patients with Thoracic Aortic Aneurysm

Dorinna Mendoza | Community Health Completed

Interaction Between Choice of Anticoagulation, Antiplatelet Therapy and Access Site on Mortality and Bleeding after Percutaneous Coronary Intervention: Insights from the California National Cardiovascular Data Registry ( NCDR) and KP PCI Registry

Femi Philip | Community Health Completed

KP Post-PCI Outcomes and Resource Utilization Study, and Development and Validation of a KP Post-PCI Risk Calculator

Matt Solomon | Industry Ongoing

KP Real-world Heart Monitoring StrategY Evaluation, Treatment Patterns and Health Metrics (RHYTHM) Study

Matt Solomon, Alan Go | Industry Ongoing

Long-Term Echocardiographic and Clinical Outcomes of Patients Receiving Transcatheter Aortic Valve Replacement within Kaiser Permanente Northern California

Emily Perdoncin | Community Health Ongoing

Long-term follow up of maternal outcomes in peripartum cardiomyopathy

Seema Pursnani | Other

Long-Term Outcome in Unruptured Brain Arteriovenous Malformation Patients

Helen Kim | NIH

Management and outcomes of patients with valvular heart disease

Matt Solomon, Alan Go | Physician Researcher Program | View Summary Completed

MEDTRONIC APOLLO: Transcatheter Mitral Valve Replacement with the Medtronic Intrepid™ TMVR System in patients with severe symptomatic mitral regurgitation

Jacob Mishell | Industry Ongoing

MITRALIGN CLPR- 010 SCOUT: Early Feasibility Of The Mitralign Percutaneous Tricuspid Valve Annuloplasty System (Ptvas) For Symptomatic Chronic Functional Tricuspid Regurgitation CLPR-010

Andrew Rassi | Industry Ongoing

Multicenter Arteriovenous malformation Research Study (MARS) extension

Jon Zaroff, Helen Kim | NIH Ongoing

Natural History of Thoracic Aortic Aneurysm and Acute Aortic Dissection

Matt Solomon | Community Health

No Differences in ED Visits, Hospitalizations, or Mortality Among Heart Failure Patients with Remote Telemonitoring

Amir Axelrod, Andrew Ambrosy, Alan Go | Delivery Science Grants Program | View Summary Completed

Optimizing Management of Valvular Heart Disease

Matthew Solomon, MD, PhD | Physician Researcher Program Ongoing

Outcomes of the Heart Health for South Asians (HHSA) Program

Seema Pursnani | Other

Periprocedural Code Status for TAVR

Gwen Bernacki | Other

PIONEER-HF: A large, multi-center randomized clinical trial of sacubitril- valsartan versus enalapril in heart failure

Drew Ambrosy | Industry Ongoing

Polygenic Risk Score and Early-onset Coronary Heart Disease in the GERA Cohort

Jamal Rana, Carlos Iribarren | Targeted Analysis Program Ongoing

Predicting Adverse Outcomes and Poorer Quality of Life After TAVR is Challenging in Real World Populations

Ed McNulty, Alan Go | Delivery Science Grants Program | View Summary Completed

Predictors of Post-PCI Resource Utilization and Outcomes

Matt Solomon | Industry

Pregnancy outcomes in women with cardiovascular disease: a retrospective cohort study from Kaiser Permanente Northern California

Seema Pursnani | Community Health Completed

Prevalence and relationship of Pre-Diabetes with risk of Atherosclerotic Cardiovascular (ASCVD) Events in Adults across Kaiser Permanente Northern California

Jamal Rana | Community Health Ongoing

Pulse Pressure, Treatment Intensity in Participants of the SPRINT trial

Ashok Krishnaswami | Other Ongoing

Rate versus Rhythm Control in Young Patients with Atrial Fibrillation: The KP YOUNG-AF Study

Matthew Solomon | Community Health Completed

Severe Hypoglycemia and Risk of Atherosclerotic Cardiovascular Disease (ASCVD) in Patients with Diabetes

Jamal Rana | Community Health Completed

Status and impact of Ideal Cardiovascular Health, as defined by American Heart Association, among KPNC population

Jamal Rana | Community Health Completed

Systematic Review of the role of age in cardiac imaging

Ashok Krishnaswami | Other Ongoing

The Kaiser Permanente Cardiovascular Health Enhancement and Monitoring for Oncology (KP CHEMO) study

Samir Thadani, Andrew Ambrosy | Delivery Science Grants Program Ongoing

The PERFUSE SCAD Registry

Sahar Naderi | Other Ongoing

The Use of Natural Language Processing to Characterize Episodes of Outpatient Worsening Heart Failure within an Integrated Health Care Delivery System

Ambrosy, Andrew, MD | Community Health Completed

Ticagrelor vs. Clopidogrel in Acute Coronary Syndromes: A Real-World, Community-Based Comparison of Ischemic and Bleeding Outcomes

Amit Sachdeva | Community Health Completed

Transcatheter Mitral-Valve Repair in Patients with Heart Failure and Functional Mitral Regurgitation – Potential Scope and Clinical Benefit of Early Adoption at an Integrated Healthcare Delivery System

Andrew Ambrosy | Industry

Understanding the impact of race/ethnicity and gender on cardiovascular outcomes following CABG

Seema Pursnani | Other

Use and outcomes of CT angiography

Jamal Rana, Alan Go | Delivery Science Grants Program | View Summary Completed

Use of Elixhauser Comorbidity Index in risk stratifying participants referred for Permanent Pacemaker placement

Ashok Krishnaswami | Other Ongoing

Validation of a Novel Algorithm for Emergency Department Patients with Possible Acute Coronary Syndromes Following the Transition to a High-Sensitivity Troponin Assay

Dustin Mark, Mary Reed | Delivery Science Grants Program | View Summary Completed

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